The Amelioration of Hypervitaminosis D in Rats with Vitamin A
نویسندگان
چکیده
The administration of relatively large amounts of vitamin A to hypervitaminotic D rats decreases the toxicity of this condition as evidenced by increased longevity, better weight gain, decreased soft tissue calcification and by considerable improvement in the histologic appearance of osseous structures.
منابع مشابه
Effects of Hypervitaminosis a and D on Skeletal Metabolism.
The feeding of escessive amounts of vitamin D to animals causes pathological changes in the skeleton and calcification of soft tissues (l-4). Hypervitaminosis A causes bone fragility. Spontaneous fractures occur in growing rats, whereas in the adult rat only rarefaction develops (5-8). Although excesses of each vitamin cause specific pathological changes, the concomitant feeding of toxic amount...
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BACKGROUND/AIM Vitamin D3 has increased risk of toxicity due to its common use in multivitamin preparations. Vitamin K and vitamin A play an important role in vitamin D action. The goal of the current study was to compare the protective effects of vitamin K and vitamin A on the modulation of hypervitaminosis D3 toxicity in rats by assessing serum calcium, renal function tests, cardiac enzymes, ...
متن کاملA case report of hypervitaminosis D in 2 months old infant
Introduction Vit D level is low in human milk (20-60 IU/Lit) thus dialy supplement of 400 Vit D is advised since birth for all infants. On the other hand upper limit dose for long term Vit D intake is 1000 IU/day for children less than one year of age. Excessive Vit D more than upper limit by physicians or parents can cause hypervitaminoseD. We report a rare case of hypervitaminose D in two mon...
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The effect of alkali (Sodium Bicarbonate) on metastatic calcification produced by Hypervitammosis D (ergocalciferol) was studied in rats. Six organs e.g. kidneys, heart, lungs, stomach, aorta and liver of the rats were examined for evidence of calcification. Six out of ten rats receiving vitamin D alone and seven out of ten rats receiving vitamin D and sodiumbicarbonate in combination, showed c...
متن کاملMetabolism of retinol-binding protein and vitamin A during hypervitaminosis A in the rat.
Vitamin A is normally transported in plasma as retinol bound to a specific protein, retinol-binding protein (RBP). Detailed studies were conducted to examine the effects of excess vitamin A on the plasma concentration and metabolism of RBP, and to obtain information about vitamin A transport in the hypervitaminotic state. Two separate experiments were conducted. In the first (Study I, 99 days),...
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عنوان ژورنال:
- The Journal of Experimental Medicine
دوره 115 شماره
صفحات -
تاریخ انتشار 1962